The first official description of the approved U.S. 80 appeared in the U.S. numbered log that AASHO printed in April 1927:
United States Highway No. 80.
Total Mileage, 2,726
Georgia Beginning at Savannah via Swainsboro, Dublin, Jeffersonville, Macon, Knoxville, Talbottom to the Georgia-Alabama State line at Columbus.
Alabama Beginning at the Georgia-Alabama State line at Columbus via Tuskegee, Montgomery, Selma, Demopolis, Livingston to the Alabama-Mississippi State line west of Cuba.
Mississippi Beginning at the Alabama-Mississippi State line west of Cuba via Kewanee, Meridian, Newton, Forest, Jackson, Vicksburg to the Mississippi-Louisiana State line at Delta.
Louisiana Beginning at the Mississippi-Louisiana State line at Delta via Tallulah, Royville, Monroe, Ruston, Arcadia, Minden, Shreveport to the Louisiana-Texas State line east of Waskom.
Texas Beginning at the Louisiana-Texas State line east of Waskom via Marshall, Longview, Mineola, Dallas, Fort Worth, Eastland, Abilene, Big Spring, Pecos, San Martine, Van Horn, El Paso to the Texas-New Mexico State line south of Anthony.
New Mexico Beginning at the Texas-New Mexico State line south of Anthony via Los Cruces, Deming, Lordsburg to the New Mexico-Arizona State line west of Rodeo.
Arizona Beginning at the New Mexico-Arizona State line west of Rodeo via Douglas, Bisbee, Tombstone, Benson, Tucson, Florence, Mesa, Phoenix, Buckeye, Gila Bend, Sentinel, Yuma to the Arizona-California State line at Yuma.
California Beginning at the Arizona-California State line west of Yuma via El Centro, Jacumba to San Diego.